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Forskolin topical for tan?


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#1 gaskibba

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Posted 05 March 2007 - 05:46 PM

Found interesting reference about topical use of Forskolin for inducing a tan.
News Focus
SKIN BIOLOGY:
A Healthy Tan?
Ingrid Wickelgren
Science 2 March 2007:
Vol. 315. no. 5816, pp. 1214 - 1216
DOI: 10.1126/science.315.5816.1214

"MSH analogs may not work in redheads with two damaged genes for MC1R proteins, however. Other teams are therefore aiming compounds downstream in the MC1R pathway. Fisher, D'Orazio, now at the University of Kentucky College of Medicine in Lexington, and their colleagues created a spectacular artificial tan in their redheaded rodents by smearing the shaved animals daily with the small molecule forskolin, a natural product in some teas that stimulates adenyl cyclase activity in cells. The forskolin-induced tan protected UV-exposed mice against sunburn and the production of DNA adducts, a sign of DNA damage. In redheaded MC1R-lacking mice that also had defective DNA repair enzymes, and thus are prone to UV-induced tumors, forskolin significantly reduced the number of such tumors compared to similar mice in a control group, Fisher says. Fisher has co-founded a firm, Magen Biosciences in Cambridge, Massachusetts, that is now trying to develop drugs that hit molecules more specific to the tanning pathway, because virtually all cells contain adenyl cyclase."

Wondering if anyone here had ever used the stuff topically?

#2 Supnut

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Posted 05 March 2007 - 07:10 PM

I tried this about three years ago and was able to produce a spot that looked like a very light birth mark. It was proof of concept but I didn't experiment further.

Benson mentioned a thread on this over at M&M last year that I never got around to looking at. I may try this sometime this year.

I was unaware of the redhead tanning potential. Interesting to say the least.



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#3 mallela

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Posted 01 December 2008 - 02:53 AM

QUOTE(Supnut @ Mar 5 2007, 07:10 PM) View Post
I tried this about three years ago and was able to produce a spot that looked like a very light birth mark. It was proof of concept but I didn't experiment further.

Benson mentioned a thread on this over at M&M last year that I never got around to looking at. I may try this sometime this year.

I was unaware of the redhead tanning potential. Interesting to say the least.

i am here with providing copy paste from PASPCR news letters september 2006 volume 14 number3---

John D’Orazio discussed the induction of eumelanin
synthesis in mice that lack functional melanocortin 1
receptor (mc1r) expression using topical application of
forskolin. Melanocytes from these mice are unable to
respond to melanocyte stimulating hormone due to the
lack of the receptor. In humans, reduced activity is a
risk factor for melanoma. Forskolin bypasses the receptor
by inducing production of cyclic AMP and thus
stimulating melanogenesis. Pheomelanotic mice were
found to produce eumelanin following topical application
of forskolin, which protected the mouse skin against
UV-induced damage. While forskolin itself may not be
useful as a topical treatment in humans due to its effect
on multiple pathways, the group is pursuing the
use of other molecules with similar properties.

==============================================
Are there any trails on human skin for repigmentation of hair or skin tan with double blind controls .

#4 mallela

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Posted 01 December 2008 - 02:54 AM

QUOTE(Supnut @ Mar 5 2007, 07:10 PM) View Post
I tried this about three years ago and was able to produce a spot that looked like a very light birth mark. It was proof of concept but I didn't experiment further.

Benson mentioned a thread on this over at M&M last year that I never got around to looking at. I may try this sometime this year.

I was unaware of the redhead tanning potential. Interesting to say the least.

i am here with providing copy paste from PASPCR news letters september 2006 volume 14 number3---

start of copy---John D’Orazio discussed the induction of eumelanin
synthesis in mice that lack functional melanocortin 1
receptor (mc1r) expression using topical application of
forskolin. Melanocytes from these mice are unable to
respond to melanocyte stimulating hormone due to the
lack of the receptor. In humans, reduced activity is a
risk factor for melanoma. Forskolin bypasses the receptor
by inducing production of cyclic AMP and thus
stimulating melanogenesis. Pheomelanotic mice were
found to produce eumelanin following topical application
of forskolin, which protected the mouse skin against
UV-induced damage. While forskolin itself may not be
useful as a topical treatment in humans due to its effect
on multiple pathways, the group is pursuing the
use of other molecules with similar properties.
---end of copied material
==============================================
Are there any trails on human skin for repigmentation of hair or skin tan with double blind controls .




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