QUOTE(Beast1226 @ Dec 30 2006, 07:30 AM)

dnp in a shampoo bottle, ha jk
DNP is the most effective and legal to purchase/own, just not legal to use on humans-- even yourself. However it is also dangerous; the LD50 is close to the ED50, and even if you don't kill yourself you will induce extreme oxidative stress in your body, the long-term effects of which on your mitochondria I wouldn't think are very good... given the damage that can accumulate from far more moderate catecholamine-induced thermogenesis.
Then you have drugs like the amphetamine-like substitute phenethylamines, the most popular legal OTC one being ephedrine in combination with caffeine, and sometimes aspirin. These drugs will suppress your appetite for about a month, and will moderately keep stimulating your metabolism beyond that. I get prescription Dexedrine (dextroamphetamine) for ADD and allow me to assure you, it's no panacea. Other drugs like nicotine, etc have similar effects here. Other drugs like OEA/SEA can be anorectic without the metabolic increase, though I can't see them working past a month or so either. Hoodia works in lab tests, but the actual supplement forms don't contain enough P57 to do anything last I checked.
Then you have PPARalpha-agonists like seasamin, TTA, etc, which work like fibrates in a way, and shift your body from burning carbs to fat. I think seasmin is probably your best bet for safety here, as fibrates can cause the breakdown of muscle tissue and even death, and I think-- though I might be wrong-- the specific risk between the PPARalpha agonists is how hydrophilic they are; as an oil sesamin should be hydrophobic and thus present less risk, but you might want to double check that shit on Pubmed.
Green tea is also good shit, having a host of effects that promote fat loss, principally thought to be through COMT inhibition allowing your norepinephrine/epinephrine to survive longer, thus raising your metabolism.
But really, the effects of any of these drugs, in part or combination, are modest. The main thing for weight loss is diet, followed by exercise. Drugs cannot change or alter that.
If you want safe and effective, there is really no substitute for diet and exercise. Drugs just make it somewhat more effective at the cost of risk, but cannot replace it, unless they induce behavioral changes that effect diet and exercise.
Also, all the stimulants, including clen, can disrupt sleep, and disrupted sleep WILL make you hungrier and decrease secretion of HGH during the night. This may or may not offset the drug-induced thermogenesis.
Finally, if you're a whitey, get some sunlight. A hormone called MSH is released upon exposure to UV light, and us white dudes have very low baseline values of it relative to people with darker skin, but we benefit much quicker from exposure to UV. So consider getting some sunlight a supplement, which can be combined with doing some cardio at the same time. We're not vampires... garlic and sunlight are both quite healthy.