Hopefully you can chime in here Anthony as I've read some of your articles on the topic of anti-estrogens, and you seem to have an advanced understanding of how they all work.

For a person who has existing case of gynecomastia are nolvadex/clomid and/or aromatize inhibitors useful in reducing gyno that has been present for 2 or more years? It's common knowledge now how they are used to prevent this problem but how about in regards to it's treatment? Is the only prognosis through surgery or are these anti-estrogens capable of actually reducing/removing a developed case? Will the taper off at the end of a cycle of an anti-estrogen eventually lead to a rebound?

I should note that in this case it was likely caused by elevated prolactin levels, and although im sure anti-estrogens would play a major role, a prolactin inhibitor such as Bromocriptin or Dostinex (Cabergoline) may also be necessary. From the blood work both estrodiol and testosterone apparently checked in normal however prolactin levels on a range of 3-18 turned in at 29. There was also no existing use of prohormones or AAS, only a medication known to increase prolactin via dopamine (D2) inhibition.

I hope this wasn't too lengthy but I wanted to provide everything that might be relevant.

Any possibility of a rebound effect once one comes off letro?

I concur, Ant. I've used their Nolva with success.
Any idea on a dosing schedule for the letro to abolish gyno?

Good deal. Thanks.

Well that's very encouraging as alot of the old school of thought on this is that surgery is the only option. What i don't understand is how a lump that has already formed is actually reduced, I mean since estrogen is essentially it's fuel source it does make sense that with that out of the way it wouldn't get worse, however through what mechanism does this actually cause it to dissipate? Just curious and thanks for your response.

2.5mg a day til it stops hurting?

So you are talking about a gyno reaction, the actual process was halted.

What I'd be interested in finding is a solution to literally already well formed breast tissue. It's not hurting, it's not doing anything, it's just there, like a gland. A gland I can't imagine going away no matter what you do to stop it's growth.

Does this make sense?

I understand letro would be good to kill the growth happening when on cycle, but once it's there I'm still not convinced anything beyond surgery will actually get rid of it.


I think half the reason I have problems with this stuff is because of my previous attempts at getting rid of the little bit I had when I got started with all of this... And it always feels as if it's going away every time I've tried, but as soon as I come off I'm right back to where I was...

Not to sound pompous, but there are already dozens of very in depth threads dealing with gyno and the non-surgical reduction of it.

With that said, keep in mind that Letro is non-steroidal and has unfavorable side effects that are not shared by the steroidal AI's. Furthermore, aromatase expression/stablity is upregulated by these NS compounds, whereas the steroidals pose less of a problem in this regard. IOW, I favor aromasin (exemstane) over Letrozole. As said, this has all been discussed ad nauseam.

also, 2.5 mg --Is that a low concentration? That seems like quite a bit and will leave other systems out of whack which is what I think caused my body it's stress previously...

yeah, thats not a low dose. And, letro is far from being an end-all cure for gyno.

As I recall from the literature anastrozole failed to reduce pubertal gyno in a big human study. I don't recall a smilar study for letro, is there one for aromasin? The only study I've seen that showed efficacy in reducing pubertal gyno (in grown men) was nolva.

abrogated means to abolish so in effect the article posted above is saying the changes occuring can be abolished but I'm not sure they mean the actual gland size prior to this bout can be gotten rid of..

believe me, I would like, just as much as anyone else, for this to be the case, because I'd really like it to work but the only thing it seems to ever accomplish in the long run is more imbalance...

I concur. I sang praises for ATD a year ago for removing over half of the appearance of my pubertal gynecomastia, such that I had a normal looking chest for the first time. However, upon 2-3 weeks of recovery from the AI, things were looking the same if not slightly worse than they had previously.

I won't speculate about increased sensitivity to E2 after these attempts at reduction, but I will say its possible/likely that breast tissue will shrink when you use an AI similarly to how the testes shrink when they lose their growth factor (LH), but once the hormonal homeostasis is returned, the tissue returns to normal size.

I think it is an exercise in futility to use non-surgical routes; this even applies to SERMs, as the 2-3 studies done with gynecomastia were not controlled and had somewhat poor methodology (not blaming the researchers, it was the best they could do with the available data). However, given the possible success of SERMs in those studies, 20mg ED for 3-9 months would be the closest thing to a clinically supported treatment protocol that currently exists.

Anthony what do you mean got rid of your gyno? Did a pre existing lump disappear?

B-u\m*p

BUMP

also
is it best to use letro on cycle or off cycle on a pre-existing gyno?

how long did it take for yours to go away at 2.5mg/day?

thanks

how bad it was for joints ?

letro @ 0.625mg ED kills my joints =C

i know that tamox reduses plazma of letro, but how about letro @ 1.25ED and tamox @ 20mgED ?

Sorry to rehash an old thread, but blood tests and the prior medication I was on helped my endocrinologist in confirming that the type of gyno I've experienced is prolactin induced. Estogen also showed up lower than usual on the blood work, and he plans to prescribe me Dosintex after an MRI to check for a benign pituitary tumour which may be present in Hyperprolactinemia cases.
My question is what is the prognosis for cases were prolactin is the culprit, as AAS and elevated estrogen related concerns don't seem to apply in this case? How long would you speculate these symtoms would be allieviated?

P.S. Anthony I found your new article in Mind and Muscle on Dostinex very informative, and useful as i'll be on that very soon. Thanks for your contribution

Two questions:

I have heard that once gynecomastia has been existent for more than 2 years the only way to remove it is by surgery. Is there another methodfor lon-standing gyno?

Why does Nolvadex affect the joints?

He was referring to letro's effect on the joints... I beleive nolvadex should have positive or no effect on joints (it has positive effects on bone density, I know that much).